The inter- and intra- molecular G-quadruplex structures generated by 3D-NuS are categorized into 17 classes of G-quadruplex folds. In which, Q1 to Q5 (frequently found) and Q14 to Q17 (rarely found) are monomeric folds, while Q6 to Q9 are dimeric folds. In contrast, Q10 to Q13 are intermolecular (tetrameric) in nature. Different classes of G-quadruplex folds are given in Figure 3. The user can check documentation page before giving input sequences and choose the desired class & sub-class according to requirement [Note: If the category of the molecule is not defined by user, then default values in the categories will be considered for molecule generation]. Then, user should select the desired length for the G-quadruplex. Here, length denotes the number of nucleotides in one strand.
Click 'Submit' button to generate the 3-dimensional model. User can view the generated 3D structure in the given molecule viewer or 'Download' the coordinates in protein data bank (PDB) file format to view in other molecule visualizers.