Lab

Thenmalarchelvi Rathinavelan

Molecular Biophysics

 


         Research Interests


Bacterial glycobiology

   Many Gram-negative bacterial surfaces are covered with surface structures called capsules. Capsules comprise of polysaccharides (CPS) with molecular weights in the range of 105-106 Daltons. A multimeric protein complex is used to translocate the CPS onto the bacterial surface. Since CPS of Gram-negative bacteria contribute a large extent in bacterial pathogenicity, it is important to investigate CPS translocation mechanism. By considering E. coli. as a model system, we will study the CPS translocation mechanism in E. coli. by employing computational and NMR methods.



Transition state structures of proteins

   Transition state structures have a key role in protein folding and assembly pathways. Hence, it is very important to understand such structural states. By applying NMR method, we will determine the transition states of smaller proteins such as B1 domain of streptococcal protein G (GB1/protein G) and acyl coenzyme A binding protein (ACBP).



Nucleic acids…Protein interaction

  Nucleic acids…protein interaction has an important role in regulating biological functions. Here, we will apply NMR and molecular dynamics simulation methods to understand nucleic acids…protein interaction in Saccharomyces cerevisiae.





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